CAS No. 808118-40-3
Chemical Information
| IUPAC Name | 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid | |
|---|---|---|
| CAS Number | 808118-40-3 | |
| Molecular Formula |
C19H16N2O5 |
|
| Molecular Weight (MW) | 352.34 | |
| SMILES | CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3 | |
| InChIKey | YOZBGTLTNGAVFU-UHFFFAOYSA-N |
Biological Activity
Roxadustat (FG-4592) is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor. By inhibiting HIF prolyl hydroxylase enzymes, Roxadustat stabilizes HIF-1α and HIF-2α transcription factor subunits, preventing their degradation and promoting functional HIF complex activation. This response directly upregulates the transcription of genes essential for erythropoiesis and iron metabolism, including erythropoietin (EPO), thereby promoting red blood cell production and modulating cellular oxygen-sensing pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(198.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
70 mg/mL
(198.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Roxadustat (FG-4592) Mechanism of Action: HIF-PH Inhibition in Erythroid Progenitor Cell Research
- Roxadustat (FG-4592) Clinical Trials
- Roxadustat (FG-4592) Working Concentration | Cell Culture | Treatment
- Roxadustat (FG-4592) Solubility in DMSO
- Roxadustat (FG-4592) Stock Solution
- Roxadustat (FG-4592) Storage
- Roxadustat (FG-4592) Stability
- Roxadustat (FG-4592) Combination Database
- Roxadustat (FG-4592) Molecular Weight
- Roxadustat (FG-4592) SMILES
- Roxadustat (FG-4592) Chemical Structure (2D and 3D)
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