CAS No. 125572-93-2
Batch:
Purity:99.49
Chemical Structure
Check the
Rotigotine Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 125572-93-2 | |
|---|---|---|
| Molecular Formula |
C19H25NOS.ClH |
|
| Molecular Weight (MW) | 351.94 |
Rotigotine Hydrochloride is a potent dopamine receptor agonist with high affinity for the dopamine D3 receptor (Ki 0.71 nM), D2, D5, and D4 receptors (Ki 4-15 nM), and D1 receptor (Ki 83 nM). It also acts as a partial agonist at 5-HT1A receptors and an antagonist at α2B-adrenergic receptors. Through activation of dopaminergic signaling pathways, rotigotine modulates neurotransmission and exhibits neuroprotective functions in neuronal models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.