CAS No. 914462-92-3
Batch:
Purity:99.83
Chemical Structure
Check the
Rolapitant hydrochloride hydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 914462-92-3 | |
|---|---|---|
| Molecular Formula |
C25H26F6N2O2.ClH.H2O |
|
| Molecular Weight (MW) | 554.95 |
Rolapitant hydrochloride hydrate is a long-acting, highly selective neurokinin-1 (NK1) receptor antagonist. By competitively binding to central and peripheral NK1 receptors, it blocks the binding of substance P and inhibits downstream neurokinin signaling pathways. This blockade suppresses substance P-mediated activation in the central nervous system, effectively reducing emetic signaling and preventing vomiting responses in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(180.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Rolapitant hydrochloride hydrate Solubility in DMSO
- Rolapitant hydrochloride hydrate Stock Solution
- Rolapitant hydrochloride hydrate Storage
- Rolapitant hydrochloride hydrate Stability
- Rolapitant hydrochloride hydrate Molecular Weight
- Rolapitant hydrochloride hydrate Chemical Structure (2D and 3D)
- Rolapitant hydrochloride hydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.