CAS No. 1443530-05-9

Batch: Purity:96.55
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Rogaratinib Chemical Structure
Chemical Structure
Check the Rogaratinib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperazin-2-one
CAS Number 1443530-05-9
Molecular Formula

C23H26N6O3S
Molecular Weight (MW) 466.56
SMILES CC1=CC2=C(C(=C1)OC)SC(=C2)C3=C4C(=NC=NN4C(=C3COC)CN5CCNC(=O)C5)N
InChIKey HNLRRJSKGXOYNO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Rogaratinib (BAY-1163877) is a potent pan-FGFR inhibitor that targets FGFR1 (IC50 1.8 nM), FGFR2 (IC50 < 1 nM), FGFR3 (IC50 9.2 nM), and FGFR4 (IC50 1.2 nM). By blocking receptor autophosphorylation, it suppresses downstream FGFR signaling pathways, including MAPK and AKT/mTOR. This inhibition leads to reduced cell proliferation and induces apoptosis in cancer models harboring FGFR genetic alterations or elevated mRNA expression. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 8 mg/mL (17.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.