CAS No. 1127308-52-4
Chemical Structure
Check the
ROCK inhibitor-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-ylbenzamide | |
|---|---|---|
| CAS Number | 1127308-52-4 | |
| Molecular Formula |
C₂₁H₂₀N₂O₂ |
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| Molecular Weight (MW) | 332.4 | |
| InChIKey | JRVSFZKYQCETAH-OAHLLOKOSA-N |
ROCK inhibitor-2 is a potent, selective small-molecule dual inhibitor targeting Rho-associated protein kinases ROCK1 and ROCK2. By inhibiting ROCK kinase activity, it blocks downstream cytoskeletal signaling, disrupting actin-myosin contractility and cellular dynamics. Consequently, this dual inhibition leads to functional downstream phenotypes, effectively inhibiting cell migration and reducing cell-in-cell structure formation in U2OS osteosarcoma cells. [1]
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Note: Technical data last updated: Sep 1, 2026.