CAS No. 490-31-3
Batch:
Purity:99.57
Chemical Structure
Check the
Robinetin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one | |
|---|---|---|
| CAS Number | 490-31-3 | |
| Molecular Formula |
C15H10O7 |
|
| Molecular Weight (MW) | 302.24 | |
| SMILES | OC1=CC=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O | |
| InChIKey | SOEDEYVDCDYMMH-UHFFFAOYSA-N |
Biological Activity
Robinetin is a natural plant flavonol and HIV-1 integrase inhibitor that dose-dependently inhibits viral integrase cleavage and integration. By disrupting microbial nucleic acid pathways, robinetin suppresses DNA synthesis in Proteus vulgaris and RNA synthesis in Staphylococcus aureus. Additionally, robinetin efficiently attenuates egg yolk phosphatidylcholine membrane lipid peroxidation and hemoglobin A glycosylation, protecting membrane lipids and functional proteins against oxidative and non-enzymatic modification. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.