CAS No. 1258296-60-4
Batch:
Purity:98.53
Chemical Structure
Check the
RO495
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[(2-amino-6-methylpyrimidin-4-yl)amino]-4-pyridinyl]-2,6-dichlorobenzamide | |
|---|---|---|
| CAS Number | 1258296-60-4 | |
| Molecular Formula |
C17H14Cl2N6O |
|
| Molecular Weight (MW) | 389.24 | |
| SMILES | CC1=CC(=NC(=N1)N)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl | |
| InChIKey | LNGDQKGREFSTHB-UHFFFAOYSA-N |
RO495 is a small-molecule inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2). By targeting TYK2, it suppresses the activation of downstream signal transducer and activator of transcription proteins within the JAK/STAT signaling pathway. This inhibition impairs cytokine-mediated signal transduction, thereby dampening inflammatory cascades and modulating immune cell responses associated with autoimmune signaling networks. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.