CAS No. 1062243-51-9
Batch:
Purity:99.87
Chemical Structure
Check the
Ro3280
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | |
|---|---|---|
| CAS Number | 1062243-51-9 | |
| Molecular Formula |
C27H35F2N7O3 |
|
| Molecular Weight (MW) | 543.61 | |
| SMILES | CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC | |
| InChIKey | DJNZZLZKAXGMMC-UHFFFAOYSA-N |
Ro3280 is a potent and selective inhibitor of Polo-like kinase 1 (PLK1) with an IC50 of 3 nM. Targeted inhibition of PLK1 disrupts mitotic spindle assembly and chromosome alignment during mitosis, leading to cell cycle arrest at the G2/M phase. Downstream, this persistent mitotic blockade impairs tumor cell proliferation and promotes programmed cell death through activation of apoptotic signaling pathways.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.