CAS No. 920022-47-5

Batch: Purity:99.98
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RO 5028442 (RG7713) Chemical Structure
Chemical Structure
Check the RO 5028442 (RG7713) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 920022-47-5
Molecular Formula

C25H28ClN3O2
Molecular Weight (MW) 437.96
SMILES CN(C)CCN1C=C(C2=C1C=C(C=C2)Cl)C(=O)N3CCC4(CC3)C5=CC=CC=C5CO4

Biological Activity

RO 5028442 (RG7713) is a brain-penetrant vasopressin 1a (V1a) receptor antagonist. By selectively inhibiting V1a receptor activation, it blocks vasopressin-mediated intracellular calcium signaling and downstream neuroendocrine pathways. This targeted antagonism modulates central vasopressinergic neurotransmission involved in social cognition and behavioral regulation in animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 5 mg/mL (11.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Manning M, et al. J Neuroendocrinol. 2012;24(4):609-28.

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Note: Technical data last updated: Sep 1, 2026.