CAS No. 946387-07-1
Batch:
Purity:99.94
Chemical Structure
Check the
RN-1734
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide | |
|---|---|---|
| CAS Number | 946387-07-1 | |
| Molecular Formula |
C14H22Cl2N2O2S |
|
| Molecular Weight (MW) | 353.31 | |
| SMILES | CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl | |
| InChIKey | IHYZMEAZAIFMTN-UHFFFAOYSA-N |
RN-1734 is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist that inhibits human TRPV4, mouse TRPV4, and rat TRPV4. By blocking TRPV4-mediated calcium influx, it modulates downstream cellular pathways, leading to reduced production of proinflammatory cytokines such as TNF-α and IL-1β, alleviation of demyelination, and suppression of glial cell activation in experimental models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 71 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.