CAS No. 2641998-63-0

Batch: Purity:99.03
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RMC-6291 (Elironrasib) Chemical Structure
Chemical Structure
Check the RMC-6291 (Elironrasib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-(dimethylamino)-4-methylpent-2-ynoyl]-N-[(2S)-1-[[(6S,8S,14S)-22-ethyl-21-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-18,18-dimethyl-9,15-dioxo-5,16-dioxa-2,10,22,28-tetrazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),20,23(27),24-tetraen-8-yl]amino]-3-methyl-1-oxobutan-2-yl]-4-fluoro-N-methylpiperidine-4-carboxamide
CAS Number 2641998-63-0
Molecular Formula

C55H78FN9O8
Molecular Weight (MW) 1012.26
InChIKey HJNFYLSFWYRSHS-CMZSUCOPSA-N

Ordering Information

Biological Activity

RMC-is an orally bioavailable, covalent tri-complex inhibitor of active GTP-bound KRASG12C (KRASG12C(ON)). Upon entering tumor cells, RMC-binds cyclophilin A to form a tri-complex with GTP-bound KRASG12C, sterically preventing effector engagement and shutting down downstream RAS/MAPK signaling. This targeted pathway inhibition leads to suppressed cell viability, induced apoptosis, and robust tumor regression in preclinical models of KRASG12C-mutant cancers. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (98.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.