CAS No. 1342278-01-6
Batch:
Purity:98.49
Chemical Structure
Check the
RKI-1447
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea | |
|---|---|---|
| CAS Number | 1342278-01-6 | |
| Molecular Formula |
C16H14N4O2S |
|
| Molecular Weight (MW) | 326.37 | |
| SMILES | C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3 | |
| InChIKey | GDVRVPIXWXOKQO-UHFFFAOYSA-N |
RKI-1447 is a potent kinase inhibitor targeting ROCK1 (IC50 14.5 nM) and ROCK2 (IC50 6.2 nM). By inhibiting ROCK kinase activity, RKI-1447 suppresses downstream phosphorylation of myosin light chain 2 and MYPT1, suppressing actin cytoskeleton reorganization. Consequently, it impairs cancer cell migration and invasion while exhibiting robust antitumor activities in preclinical human breast cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.