CAS No. 2648855-18-7
Batch:
Purity:99.03
Chemical Structure
Check the
RK-701
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2S)-1-(4-cyanoanilino)-4-cyclopropyl-1-oxobutan-2-yl]-3,6,6-trimethyl-4-oxo-5,7-dihydro-1H-indole-2-carboxamide | |
|---|---|---|
| CAS Number | 2648855-18-7 | |
| Molecular Formula |
C26H30N4O3 |
|
| Molecular Weight (MW) | 446.54 | |
| InChIKey | OWORSODZTADOQX-IBGZPJMESA-N |
RK-701 is a potent, selective inhibitor of histone methyltransferases G9a and GLP1. It suppresses histone methyltransferase activity and inhibits the recruitment of γ-globin repressors in complex with G9a through CHD4, a component of the NuRD complex. This interaction selectively upregulates BGLT3 long non-coding RNA and induces fetal γ-globin expression in human erythroid cells and mouse models, supporting research in sickle cell disease. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.