CAS No. 87051-43-2

Batch: Purity:98.94
Check CoA
Ritanserin (R 55667) Chemical Structure
Chemical Structure
Check the Ritanserin (R 55667) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 87051-43-2
Molecular Formula

C27H25F2N3OS
Molecular Weight (MW) 477.57

Biological Activity

Ritanserin (R 55667) is a highly potent, selective, orally active, and long-acting antagonist of the 5-HT2 receptor with an IC50 of. It exhibits minimal activity against histamine H1, dopamine D2, and adrenergic receptors. By blocking 5-HT2 receptor-mediated inhibitory input, ritanserin enhances midbrain dopamine neuron firing activity and regulates downstream central neurotransmitter signaling pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 96 mg/mL
DMSO 32 mg/mL (67.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ugedo L, et al. Psychopharmacology (Berl). 1989;98(1):45-50.

Jump to

Note: Technical data last updated: Sep 1, 2026.