CAS No. 105462-24-6
Batch:
Purity:100
Chemical Structure
Check the
Risedronate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 105462-24-6 | |
|---|---|---|
| Molecular Formula |
C7H11NO7P2 |
|
| Molecular Weight (MW) | 283.11 | |
| SMILES | C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)O |
Risedronate is a nitrogen-containing bisphosphonate that acts as an inhibitor of farnesyl pyrophosphate synthase (FPPS) within the mevalonate pathway. By suppressing FPPS activity, risedronate prevents the prenylation of small GTP-binding proteins essential for cellular signaling in osteoclasts. This disruption leads to impaired osteoclast survival and function, triggering osteoclast apoptosis and suppressing osteoclast-mediated bone resorption. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 0.5MNAOH | 3.03 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.