CAS No. 1442472-39-0

Batch: Purity:99.82
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Ripretinib (DCC-2618) Chemical Structure
Chemical Structure
Check the Ripretinib (DCC-2618) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea
CAS Number 1442472-39-0
Molecular Formula

C24H21BrFN5O2
Molecular Weight (MW) 510.36
SMILES CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
InChIKey CEFJVGZHQAGLHS-UHFFFAOYSA-N

Biological Activity

Ripretinib (DCC-2618) is a switch-pocket control inhibitor targeting wild-type KIT and KIT mutants, including KIT V654A, KIT T670I (IC50 1, KIT D816H, and KIT D816V (IC50 1, as well as PDGFRα. By locking the kinase in an inactive conformation, it blocks downstream KIT and PDGFRα signaling pathways, inhibiting cell proliferation and survival in driven tumor cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (195.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Smith BD, et al. Cancer Cell. 2019;35(5):738-751.e9.

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Note: Technical data last updated: Sep 1, 2026.