CAS No. 2682114-39-0

Batch: Purity:99.33
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RIN1 (RBPJ Inhibitor-1) Chemical Structure
Chemical Structure
Check the RIN1 (RBPJ Inhibitor-1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(2-fluorophenoxy)-4-(2-methylpyrazol-3-yl)benzamide
CAS Number 2682114-39-0
Molecular Formula

C17H14FN3O2
Molecular Weight (MW) 311.31
SMILES C[N]1N=CC=C1C2=CC(=C(C=C2)C(N)=O)OC3=CC=CC=C3F
InChIKey MFSSHRCJKRDIOL-UHFFFAOYSA-N

Ordering Information

Biological Activity

RIN1 is a small-molecule inhibitor of the transcription factor RBPJ that directly disrupts the interaction between NOTCH and RBPJ. By blocking this interaction, RIN1 impairs the assembly of the canonical NOTCH transcriptional activation complex. This disruption down-regulates downstream target gene expression within the NOTCH signaling pathway, ultimately suppressing NOTCH-dependent cellular growth and proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 62 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.