CAS No. 1501-84-4

Batch: Purity:98
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Rimantadine Hydrochloride Chemical Structure
Chemical Structure
Check the Rimantadine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(1-adamantyl)ethanamine;hydrochloride
CAS Number 1501-84-4
Molecular Formula

C12H21N.HCl
Molecular Weight (MW) 215.76
SMILES CC(C12CC3CC(C1)CC(C3)C2)N.Cl
InChIKey OZBDFBJXRJWNAV-UHFFFAOYSA-N

Biological Activity

Rimantadine Hydrochloride is an antiviral agent that selectively targets the influenza A virus M2 proton channel. By specifically inhibiting the M2 ion channel, this compound blocks acid ion transport across the influenza virion membrane during endosomal acidification. Consequently, Rimantadine prevents viral uncoating and impairs viral RNA release into host cell cytoplasm, ultimately suppressing influenza viral replication. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hay AJ, et al. EMBO J. 1985;4(11):3021-4.

[2] Jing X, et al. Proc Natl Acad Sci U S A. 2008;105(31):10967-72.

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Note: Technical data last updated: Sep 1, 2026.