CAS No. 13392-28-4

Batch: Purity:99.35
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Rimantadine Chemical Structure
Chemical Structure
Check the Rimantadine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(1-adamantyl)ethanamine
CAS Number 13392-28-4
Molecular Formula

C12H21N
Molecular Weight (MW) 179.3
SMILES CC(C12CC3CC(C1)CC(C3)C2)N
InChIKey UBCHPRBFMUDMNC-UHFFFAOYSA-N

Biological Activity

Rimantadine is an orally active antiviral agent that acts as an inhibitor of the influenza A virus M2 proton channel. By targeting the M2 channel, rimantadine blocks proton translocation across the viral membrane during endocytosis, preventing viral uncoating and the release of viral ribonucleoprotein complexes into the host cell cytoplasm. This disruption of viral entry effectively suppresses influenza A virus replication in vitro and in vivo. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 36 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Schnell JR, et al. Nature. 2008;451(7178):591-5.

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Note: Technical data last updated: Sep 1, 2026.