CAS No. 700361-47-3

Batch: Purity:99.91
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Rilpivirine Hydrochloride Chemical Structure
Chemical Structure
Check the Rilpivirine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile;hydrochloride
CAS Number 700361-47-3
Molecular Formula

C22H18N6.ClH
Molecular Weight (MW) 402.88
SMILES Cl.CC1=C(NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C(=CC(=C1)\C=C\C#N)C
InChIKey KZVVGZKAVZUACK-BJILWQEISA-N

Ordering Information

Biological Activity

Rilpivirine Hydrochloride (TMC278) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 reverse transcriptase. By binding to the non-nucleoside inhibitor-binding pocket, it inhibits viral RNA-dependent DNA polymerase activity, thereby blocking viral replication and viral DNA synthesis in wild-type and NNRTI-resistant HIV-1 strains. Additionally, rilpivirine acts as an inhibitor of ATP-binding cassette transporters, including MDR1 and BCRP. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.