CAS No. 2642218-43-5
Batch:
Purity:96.41
Chemical Structure
Check the
RIG012
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,3-diethyl-4-phenylmethoxybenzo[g]indole-2,5-dione | |
|---|---|---|
| CAS Number | 2642218-43-5 | |
| Molecular Formula |
C23H21NO3 |
|
| Molecular Weight (MW) | 359.42 | |
| InChIKey | OEWZCENSPLZNPQ-UHFFFAOYSA-N |
RIGis a small-molecule antagonist of retinoic acid-inducible gene I (RIG-I) that inhibits its enzymatic activity with an ICofin an NADH-coupled ATPase assay. By targeting RIG-I, RIGeffectively blocks RIG-I-initiated signaling pathways and suppresses downstream interferon and inflammatory responses, including those triggered by viral stimuli such as SARS-CoV-2 RNA. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.