CAS No. 14897-39-3

Batch: Purity:98
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Rifamycin sodium salt Chemical Structure
Chemical Structure
Check the Rifamycin sodium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-acetyloxy-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-27-olate
CAS Number 14897-39-3
Molecular Formula

C37H46NNaO12
Molecular Weight (MW) 719.75
SMILES CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)[O-])C.[Na+]
InChIKey YVOFSHPIJOYKSH-NLYBMVFSSA-M

Biological Activity

Rifamycin sodium salt is a macrocyclic antibacterial agent that targets bacterial DNA-dependent RNA polymerase. By selectively binding to the beta subunit of the bacterial RNA polymerase complex, it inhibits the initiation of RNA synthesis and blocks transcription. This inhibition disrupts bacterial RNA production and subsequent protein synthesis, ultimately suppressing bacterial cell growth and exhibiting potent antimycobacterial activity.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (138.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.