CAS No. 390362-78-4

Batch: Purity:99.42
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RHPS 4 methosulfate Chemical Structure
Chemical Structure
Check the RHPS 4 methosulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4,16-difluoro-8,11,20-trimethyl-8-aza-20-azoniapentacyclo[11.7.1.02,7.09,21.014,19]henicosa-1(20),2(7),3,5,9,11,13(21),14(19),15,17-decaene;methyl sulfate
CAS Number 390362-78-4
Molecular Formula

C22H17F2N2.CH3O4S
Molecular Weight (MW) 458.48
SMILES CC1=CC2=C3C(=C1)N(C4=C(C3=[N+](C5=C2C=C(C=C5)F)C)C=C(C=C4)F)C.COS(=O)(=O)[O-]
InChIKey VRWGYMXWYZBBGF-UHFFFAOYSA-M

Biological Activity

RHPS4 (NSC714187) is a potent telomerase inhibitor and telomeric G-quadruplex ligand. Stabilization of telomeric G-quadruplex structures leads to telomere uncapping, dysfunction, and activation of the DNA damage response pathway. These downstream mechanisms disrupt telomere maintenance, resulting in cell cycle arrest, suppression of tumor cell proliferation, and the induction of senescence and apoptosis in cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.