CAS No. 83654-05-1
Batch:
Purity:99.23
Chemical Structure
Check the
RHC 80267
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate | |
|---|---|---|
| CAS Number | 83654-05-1 | |
| Molecular Formula |
C20H34N4O4 |
|
| Molecular Weight (MW) | 394.51 | |
| SMILES | C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1 | |
| InChIKey | RXSVYGIGWRDVQC-UHFFFAOYSA-N |
Biological Activity
RHC 80267 is a potent inhibitor of diacylglycerol lipase (DAGL). By selectively blocking DAGL activity, it prevents the enzymatic cleavage of diacylglycerol into monoacylglycerol and free arachidonic acid, thereby suppressing downstream arachidonic acid cascade signaling and prostaglandin production. In cellular models, RHC 80267 attenuates ionophore-stimulated release of arachidonic acid and modulates lipid mediator-driven pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.