CAS No. 500-65-2

Batch: Purity:99.92
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Rhapontigenin Chemical Structure
Chemical Structure
Check the Rhapontigenin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
CAS Number 500-65-2
Molecular Formula

C15H14O4
Molecular Weight (MW) 258.27
SMILES COC1=C(C=C(C=C1)C=CC2=CC(=CC(=C2)O)O)O
InChIKey PHMHDRYYFAYWEG-NSCUHMNNSA-N

Ordering Information

Biological Activity

Rhapontigenin is a natural stilbene derivative that acts as a selective inhibitor of cytochrome P450 1A1 (CYP1A1) with an IC50 of 400 nM. By inhibiting CYP1A1 activity, it blocks the metabolic activation of procarcinogens, thereby suppressing carcinogen-induced cellular damage and tumorigenesis. Furthermore, rhapontigenin exhibits antiproliferative and antioxidant properties across various cancer cell models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (197.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.