CAS No. 2794934-49-7
Batch:
Purity:99.24
Chemical Structure
Check the
RGT-018
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-2-methyl-6-morpholin-4-yl-7-oxopyrido[4,3-d]pyrimidin-8-yl]pyridine-2-carbonitrile | |
|---|---|---|
| CAS Number | 2794934-49-7 | |
| Molecular Formula |
C27H24F3N7O2 |
|
| Molecular Weight (MW) | 535.52 | |
| InChIKey | HRMKBFIINYRRDO-OAHLLOKOSA-N |
Biological Activity
RGT-018 is a potent and selective small-molecule inhibitor of son of sevenless homolog 1 (SOS1) that disrupts the protein-protein interaction between KRAS and SOS1. By blocking SOS1-mediated guanine nucleotide exchange, RGT-018 effectively attenuates downstream KRAS signaling pathways, resulting in the inhibition of cellular proliferation and survival in KRAS-driven cancer models, including non-small cell lung, colorectal, and pancreatic carcinomas. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(186.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.