CAS No. 1005504-62-0
Batch:
Purity:99.73
Chemical Structure
Check the
RG3039
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine | |
|---|---|---|
| CAS Number | 1005504-62-0 | |
| Molecular Formula |
C21H23Cl2N5O |
|
| Molecular Weight (MW) | 432.35 | |
| SMILES | C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)CC4=C(C=CC=C4Cl)Cl | |
| InChIKey | MNLHFGXIUJNDAF-UHFFFAOYSA-N |
Biological Activity
RG3039 is an orally bioavailable and brain-penetrant inhibitor of the scavenger mRNA decapping enzyme, DcpS. By inhibiting DcpS, RG3039 modulates mRNA decapping and increases the expression of survival motor neuron (SMN) protein. In mouse models of spinal muscular atrophy, treatment with RG3039 restores motor function, protects motor neurons, improves neuromuscular junction pathology, and significantly prolongs overall survival.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(6.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.