CAS No. 1215493-56-3
| IUPAC Name | N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide | |
|---|---|---|
| CAS Number | 1215493-56-3 | |
| Molecular Formula |
C20H25N3O2 |
|
| Molecular Weight (MW) | 339.43 | |
| SMILES | CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N | |
| InChIKey | VOPDXHFYDJAYNS-UHFFFAOYSA-N |
RG2833 (RGFP109) is a brain-penetrant histone deacetylase inhibitor targeting HDAC1 and HDAC3. By suppressing HDAC enzymatic activity, RG2833 increases chromatin accessibility through histone hyperacetylation and reactivates frataxin gene transcription. Downstream, restoration of frataxin protein levels alleviates mitochondrial iron accumulation, reduces oxidative stress, and attenuates neurodegenerative phenotypes in cellular and animal models of Friedreich ataxia. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
| DMSO |
68 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
68 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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