CAS No. 136831-48-6
Batch:
Purity:99.28
Chemical Structure
Check the
RG 13022
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile | |
|---|---|---|
| CAS Number | 136831-48-6 | |
| Molecular Formula |
C16H14N2O2
|
|
| Molecular Weight (MW) | 266.29 | |
| SMILES | COC1=C(C=C(C=C1)C=C(C#N)C2=CN=CC=C2)OC | |
| InChIKey | DBGZNJVTHYFQJI-RIYZIHGNSA-N |
RG 13022 is a tyrphostin-class tyrosine kinase inhibitor that selectively targets the epidermal growth factor receptor (EGFR), inhibiting receptor autophosphorylation with an IC50 of. By suppressing EGFR autophosphorylation and kinase activity, RG 13022 impairs downstream receptor signaling cascades, leading to the inhibition of cell proliferation and growth in epidermal growth factor-dependent cell systems. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(199.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.