CAS No. 2636846-41-6
Batch:
Purity:95.10
Chemical Structure
Check the
Rezatapopt
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[3-[4-[[(3S,4R)-3-fluoro-1-methylpiperidin-4-yl]amino]-1-(2,2,2-trifluoroethyl)indol-2-yl]prop-2-ynylamino]-3-methoxy-N-methylbenzamide | |
|---|---|---|
| CAS Number | 2636846-41-6 | |
| Molecular Formula |
C28H31F4N5O2 |
|
| Molecular Weight (MW) | 545.57 | |
| InChIKey | NKRKBSQLUPEVCZ-JTHBVZDNSA-N |
Rezatapopt (PC14586) is a first-in-class, selective small-molecule reactivator of the Y220C-mutated p53 protein. By binding to a unique mutation-created pocket, it stabilizes the wild-type conformation of p53 Y220C, restoring its DNA-binding ability and transcriptional activity. Reactivation of the p53 signaling pathway restores downstream tumor suppressor functions, driving transcriptomic target activation, antiproliferative responses, and significant tumor growth inhibition or regression in p53 Y220C-mutant xenograft models.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.