CAS No. 313397-13-6
Batch:
Purity:99.03
Chemical Structure
Check the
Reversan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(3-morpholin-4-ylpropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide | |
|---|---|---|
| CAS Number | 313397-13-6 | |
| Molecular Formula |
C26H27N5O2 |
|
| Molecular Weight (MW) | 441.53 | |
| InChIKey | JTRXWCLQFAZHGP-UHFFFAOYSA-N |
Biological Activity
Reversan is a pyrazolopyrimidine-based small-molecule inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). By inhibiting MRP1- and P-gp-mediated active drug efflux, Reversan prevents the extracellular transport of chemotherapeutic agents, thereby increasing intracellular drug accumulation. This enhances drug-induced DNA damage and chemosensitivity to agents such as vincristine and etoposide in tumor cells, significantly reversing multidrug resistance in neuroblastoma and glioblastoma models.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
18 mg/mL
(40.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.