CAS No. 864750-70-9
Batch:
Purity:99.94
Chemical Structure
Check the
Revefenacin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 864750-70-9 | |
|---|---|---|
| Molecular Formula |
C35H43N5O4 |
|
| Molecular Weight (MW) | 597.75 | |
| SMILES | CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)CN5CCC(CC5)C(=O)N |
Biological Activity
Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic receptor antagonist. It functions by competitively binding to muscarinic acetylcholine receptors, specifically targeting M3 receptors in airway smooth muscle. Inhibition of M3 receptor signaling blocks acetylcholine-mediated intracellular calcium mobilization, downstream smooth muscle contraction, and bronchoconstriction, thereby promoting sustained bronchodilation and relaxation of bronchial tissue.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(167.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.