CAS No. 178307-42-1

Batch: Purity:99.99
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Revaprazan Hydrochloride Chemical Structure
Chemical Structure
Check the Revaprazan Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine;hydrochloride
CAS Number 178307-42-1
Molecular Formula

C22H23FN4.HCl
Molecular Weight (MW) 398.9
SMILES CC1C2=CC=CC=C2CCN1C3=NC(=NC(=C3C)C)NC4=CC=C(C=C4)F.Cl
InChIKey MALPZYQJEDBIAK-UHFFFAOYSA-N

Ordering Information

Biological Activity

Revaprazan Hydrochloride (YH1885) is a novel reversible proton pump inhibitor that targets H+/K+-ATPase. By competitively binding to the potassium-binding site of gastric H+/K+-ATPase, it exerts potent and long-lasting acid-suppressive effects. This target inhibition effectively suppresses gastric acid secretion, leading to significant reduction of gastric mucosal damage and mucosal lesion formation in preclinical animal models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 16 mg/mL (40.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.