CAS No. 920509-32-6
Batch:
Purity:99.81
Chemical Structure
Check the
MGL-3196 (Resmetirom)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile | |
|---|---|---|
| CAS Number | 920509-32-6 | |
| Molecular Formula |
C17H12Cl2N6O4 |
|
| Molecular Weight (MW) | 435.22 | |
| SMILES | CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl | |
| InChIKey | FDBYIYFVSAHJLY-UHFFFAOYSA-N |
Resmetirom (MGL-3196) is a liver-directed, orally active selective thyroid hormone receptor β (THR-β) agonist that demonstrates 28-fold selectivity for THR-β over THR-α. Selective activation of THR-β drives hepatic lipid metabolism, stimulating mitochondrial fatty acid oxidation and decreasing intrahepatic lipid accumulation and circulating triglyceride levels while avoiding systemic THR-α-mediated cardiac toxicity. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(101.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
87 mg/mL
(199.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
87 mg/mL
(199.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- MGL-3196 (Resmetirom) Clinical Trials
- MGL-3196 (Resmetirom) Solubility in DMSO
- MGL-3196 (Resmetirom) Stock Solution
- MGL-3196 (Resmetirom) Storage
- MGL-3196 (Resmetirom) Stability
- MGL-3196 (Resmetirom) Molecular Weight
- MGL-3196 (Resmetirom) SMILES
- MGL-3196 (Resmetirom) Chemical Structure (2D and 3D)
- MGL-3196 (Resmetirom) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.