Remogliflozin etabonate (GSK189075)

For research use only.

Catalog No.S0993

Remogliflozin etabonate (GSK189075) Chemical Structure

CAS No. 442201-24-3

Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models.

Purity & Quality Control

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Biological Activity

Description Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models.
Targets
hSGLT2 [1]
(Cell-free assay)
rSGLT2 [1]
(Cell-free assay)
rSGLT1 [1]
(Cell-free assay)
hSGLT1 [1]
(Cell-free assay)
1950 nM(Ki) 2140 nM(Ki) 8570 nM(Ki) 43100 nM(Ki)

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (191.35 mM)
Water Insoluble
Ethanol ''''25 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 522.59
Formula

C26H38N2O9

CAS No. 442201-24-3
Storage powder
in solvent
Synonyms N/A
Smiles CCOC(=O)OCC1C(C(C(C(O1)OC2=NN(C(=C2CC3=CC=C(C=C3)OC(C)C)C)C(C)C)O)O)O

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00575159 Completed Drug: GSK189075|Drug: placebo Diabetes Mellitus Type 1 GlaxoSmithKline March 31 2008 Phase 2
NCT00625859 Completed Drug: GSK189075|Drug: Bupropion|Drug: Placebo Diabetes Mellitus Type 2 GlaxoSmithKline January 16 2008 Phase 1
NCT00532610 Completed Drug: GSK189075 Type 2 Diabetes Mellitus|Diabetes Mellitus Type 2 GlaxoSmithKline September 2007 Phase 1
NCT00501930 Completed Drug: GSK189075 Type 2 Diabetes Mellitus|Diabetes Mellitus Type 2 GlaxoSmithKline April 2007 Phase 1
NCT00501397 Completed Drug: ketoconazole|Drug: GSK189075 Type 2 Diabetes Mellitus|Diabetes Mellitus Type 2 GlaxoSmithKline February 2007 Phase 1
NCT00376038 Completed Drug: GSK189075 oral tablets|Drug: metformin tablets Type 2 Diabetes Mellitus|Diabetes Mellitus Type 2 GlaxoSmithKline August 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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SGLT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID