CAS No. 1622921-15-6

Batch: Purity:99.95
Check CoA
Remodelin Hydrobromide Chemical Structure
Chemical Structure
Check the Remodelin Hydrobromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;hydrobromide
CAS Number 1622921-15-6
Molecular Formula

C15H15BrN4S
Molecular Weight (MW) 363.28
SMILES C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br
InChIKey XNWBCMSPDCSWSD-UHFFFAOYSA-N

Ordering Information

Biological Activity

Remodelin hydrobromide is a potent small-molecule inhibitor of N-acetyltransferase 10 (NAT10). By inhibiting NAT10-dependent acetyltransferase activity, it effectively restores nuclear architecture and reduces nuclear shape deformities in lamin A/C-deficient and progeric cells. Consequently, this targeted intervention decreases DNA damage, enhances cellular fitness, and rescues nuclear defects associated with laminopathies and cellular aging pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (137.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.