CAS No. 1417823-67-6
Batch:
Purity:98.07
Chemical Structure
Check the
REM127
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(4-chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole | |
|---|---|---|
| CAS Number | 1417823-67-6 | |
| Molecular Formula |
C20H20Cl2N4S |
|
| Molecular Weight (MW) | 419.37 | |
| InChIKey | YWJORACHBFMAHI-UHFFFAOYSA-N |
REM127 is a small-molecule agent that restores calcium homeostasis by stabilizing the septin cytoskeleton, preventing pathological calcium influx in tauopathy models. By maintaining septin structural integrity, it enhances synaptic plasticity, decreases tau and amyloid-beta pathology, and rescues cognitive function. These mechanisms highlight the therapeutic potential of septin-targeting strategies for neurodegenerative disorders, including Alzheimer's disease and frontotemporal dementia. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 6 mg/mL |
| DMSO |
5 mg/mL
(11.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.