CAS No. 737789-87-6

Batch: Purity:99.76
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Relugolix (TAK-385, RVT-601) Chemical Structure
Chemical Structure
Check the Relugolix (TAK-385, RVT-601) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
CAS Number 737789-87-6
Molecular Formula

C29H27F2N7O5S
Molecular Weight (MW) 623.63
SMILES CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC
InChIKey AOMXMOCNKJTRQP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Relugolix (TAK-385) is a selective, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR), demonstrating potent inhibition against human GnRHR and monkey GnRHR. By competitively binding to pituitary GnRHR, it blocks endogenous GnRH signaling, preventing the secretion of luteinizing hormone and follicle-stimulating hormone, which downstream suppresses gonadal sex hormone production. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 61 mg/mL (97.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.