CAS No. 1174018-99-5

Batch: Purity:99.75
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Relebactam Chemical Structure
Chemical Structure
Check the Relebactam product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2S,5R)-7-oxo-2-(piperidin-4-ylcarbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
CAS Number 1174018-99-5
Molecular Formula

C12H20N4O6S
Molecular Weight (MW) 348.38
SMILES C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
InChIKey SMOBCLHAZXOKDQ-ZJUUUORDSA-N

Ordering Information

Biological Activity

Relebactam is a non-beta-lactam diazabicyclooctane inhibitor targeting class A (including KPC-2) and class C (AmpC) beta-lactamases. By suppressing enzyme-mediated hydrolysis of beta-lactam antibiotics, relebactam restores the antibacterial activity of co-administered carbapenems against resistant Gram-negative bacterial strains. This target inhibition protects bacterial cell wall synthesis, suppressing drug resistance in pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (200.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 70 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.