CAS No. 1019206-88-2

Batch: Purity:99.99
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Regorafenib (BAY-734506) Monohydrate Chemical Structure
Chemical Structure
Check the Regorafenib (BAY-734506) Monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1019206-88-2
Molecular Formula

C21H15ClF4N4O3.H2O
Molecular Weight (MW) 500.83
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O

Biological Activity

Regorafenib Monohydrate is a potent oral multikinase inhibitor targeting VEGFR1, VEGFR2, PDGFR-β, KIT, RET, and RAF-1. By suppressing receptor tyrosine kinase signaling and the RAF/MEK/ERK signaling axis, Regorafenib inhibits tumor cell proliferation, tumor angiogenesis, and vessel permeability in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (199.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Wilhelm SM, et al. Int J Cancer. 2011;129(1):245-55.

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Note: Technical data last updated: Sep 1, 2026.