CAS No. 923032-37-5

Batch: Purity:99.91
Check CoA
Refametinib (RDEA119) Chemical Structure
Chemical Structure
Check the Refametinib (RDEA119) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide
CAS Number 923032-37-5
Molecular Formula

C19H20F3IN2O5S
Molecular Weight (MW) 572.34
SMILES COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
InChIKey RDSACQWTXKSHJT-NSHDSACASA-N

Ordering Information

Biological Activity

Refametinib (RDEA119) is an ATP-noncompetitive inhibitor of MEK1 and MEK2. By selectively targeting MEK within the RAS/RAF/MEK/ERK signaling pathway, it prevents downstream phosphorylation of ERK (pERK), leading to inhibition of cellular proliferation. In preclinical mouse xenograft models, oral administration of refametinib effectively suppresses tumor growth and exhibits strong target engagement with minimal central nervous system penetration. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (174.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.