CAS No. 334969-03-8
Batch:
Purity:99.55
Chemical Structure
Check the
Recilisib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(E)-2-[(4-chlorophenyl)methylsulfonyl]ethenyl]benzoic acid | |
|---|---|---|
| CAS Number | 334969-03-8 | |
| Molecular Formula |
C16H13ClO4S |
|
| Molecular Weight (MW) | 336.79 | |
| InChIKey | KBEKQQJUNVQLDZ-MDZDMXLPSA-N |
Recilisib (ON01210, EX-RAD) is a small-molecule radioprotectant that activates the PI3K/AKT signaling pathway in exposed cells. By upregulating PI3K/AKT activity, it suppresses radiation-induced p53 signaling and inhibits apoptotic cell death. Consequently, recilisib enhances hematopoietic stem and progenitor cell survival, accelerates bone marrow recovery, and protects intestinal crypt cells against ionizing radiation toxicity.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.