CAS No. 1527495-76-6
Batch:
Purity:98.63
Chemical Structure
Check the
Rebamipide mofetil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1527495-76-6 | |
|---|---|---|
| Molecular Formula |
C25H26ClN3O5 |
|
| Molecular Weight (MW) | 483.94 | |
| SMILES | ClC1=CC=C(C=C1)C(=O)NC(CC2=CC(=O)NC3=CC=CC=C23)C(=O)OCCN4CCOCC4 |
Rebamipide mofetil is an orally active prodrug of rebamipide that functions as a mucoprotective agent and inducer of cyclooxygenase-2 (COX-2) expression. Rebamipide activates AMPK signaling to transcriptionally upregulate COX-2 expression without altering COX-1 levels. This COX-2 induction leads to elevated prostaglandin E2 (PGE2) synthesis, which enhances gastric mucosal defense and promotes mucosal protection against epithelial injury. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.