CAS No. 108237-91-8
Batch:
Purity:99.83
Chemical Structure
Check the
RCGD423
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 108237-91-8 | |
|---|---|---|
| Molecular Formula |
C15H11BrN2S |
|
| Molecular Weight (MW) | 331.23 | |
| SMILES | C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)Br |
RCGD423 is a small-molecule modulator of glycoprotein 130 (gp130, IL6ST) signaling that regulates cartilage development. By modulating gp130 receptor dimerization and downstream STAT3 signaling cascades, RCGD423 influences cellular proliferation and differentiation pathways. These molecular actions promote cartilage growth, preserve extracellular matrix integrity, and regulate phenotypic maintenance in chondrocytes during tissue differentiation and homeostasis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 30 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.