CAS No. 2360851-29-0
| IUPAC Name | 7-(cyclopropylmethoxy)-5-fluoro-2-[(4-hydroxycyclohexyl)sulfanylmethyl]-3H-quinazolin-4-one | |
|---|---|---|
| CAS Number | 2360851-29-0 | |
| Molecular Formula |
C19H23FN2O3S |
|
| Molecular Weight (MW) | 378.46 | |
| SMILES | OC1CCC(CC1)SCC2=NC3=CC(=CC(=C3C(=O)N2)F)OCC4CC4 | |
| InChIKey | NKZDEFKPZSLQRF-UHFFFAOYSA-N |
RBN012759 is a potent and selective small-molecule inhibitor targeting catalytic domain of poly(ADP-ribose) polymerase 14 (PARP14). Blockade of PARP14 catalytic function regulates STAT6-mediated transcriptional signaling and reprograms immune cell polarization. Downstream, inhibiting PARP14 reduces pro-tumor macrophage activity, induces localized inflammatory responses, and enhances anti-tumor immune activity within the tumor microenvironment to impede tumor progression. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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