CAS No. 328023-11-6
Batch:
Purity:99.88
Chemical Structure
Check the
Rbin-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole | |
|---|---|---|
| CAS Number | 328023-11-6 | |
| Molecular Formula |
C13H12N4S |
|
| Molecular Weight (MW) | 256.33 | |
| SMILES | CC(=C)CSC1=NC2=C(C3=CC=CC=C3N2)N=N1 | |
| InChIKey | LPCWHNSRTRBKBO-UHFFFAOYSA-N |
Rbin-1 (Ribozinoindole-1) is a potent small-molecule inhibitor of eukaryotic ribosome assembly that targets the AAA+ ATPase Mdn1. It directly inhibits the ATPase activity of recombinant full-length Mdn1 in vitro. By impairing Mdn1 function, Rbin-1 disrupts the maturation and nuclear export of pre-ribosomal subunits, ultimately blocking eukaryotic ribosome biogenesis and cellular proliferation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
19.5 mg/mL
(76.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.