CAS No. 361185-42-4
Batch:
Purity:99.08
Chemical Structure
Check the
RBC8
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-amino-4-(2,5-dimethoxyphenyl)-3-naphthalen-2-yl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | |
|---|---|---|
| CAS Number | 361185-42-4 | |
| Molecular Formula |
C25H20N4O3 |
|
| Molecular Weight (MW) | 424.45 | |
| SMILES | COC1=CC(=C(C=C1)OC)C2C(=C(OC3=NNC(=C23)C4=CC5=CC=CC=C5C=C4)N)C#N | |
| InChIKey | CLMQBVUFKIKYLU-UHFFFAOYSA-N |
RBC8 is a selective inhibitor of the small GTPases RalA and RalB that acts by blocking the interaction between Ral and its downstream effector RALBP1, demonstrating no inhibitory activity against Ras or RhoA GTPases. By selectively suppressing Ral signaling, RBC8 inhibits Ral-mediated cellular proliferation, anchorage-independent growth, and migration in cancer cells, ultimately suppressing tumor growth in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(197.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.