CAS No. 6211-32-1

Batch: Purity:98
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Rauwolscine hydrochloride Chemical Structure
Chemical Structure
Check the Rauwolscine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6211-32-1
Molecular Formula

C21H26N2O3.HCl
Molecular Weight (MW) 390.9
SMILES COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl

Biological Activity

Rauwolscine hydrochloride is a potent and selective α2-adrenergic receptor antagonist with a Ki of. By blocking α2-adrenergic receptors, it reverses agonist-induced inhibition of adenylate cyclase, leading to elevated intracellular cyclic AMP (cAMP) levels and increased norepinephrine release. These downstream actions modulate sympathetic neurotransmission and vascular smooth muscle tone, altering α2-adrenergic receptor-mediated signaling pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (17.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Doxey JC, et al. Br J Pharmacol. 1983;78(3):489-505.

[2] Goldberg MR, et al. Pharmacol Rev. 1983;35(3):143-80.

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Note: Technical data last updated: Sep 1, 2026.