CAS No. 132907-72-3

Batch: Purity:99.95
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Ramosetron Hydrochloride Chemical Structure
Chemical Structure
Check the Ramosetron Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 132907-72-3
Molecular Formula

C17H17N3O.HCl
Molecular Weight (MW) 315.8
SMILES CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4.Cl

Biological Activity

Ramosetron Hydrochloride is a potent and selective serotonin 5-HT3 receptor antagonist. By selectively binding to and inhibiting 5-HT3 receptors, it blocks serotonin-mediated signaling pathways in central and peripheral neural tissues. This receptor blockade inhibits serotonin-induced depolarization of peripheral neurons and suppresses downstream emetic signaling cascades, demonstrating robust activity against serotonin-driven physiological responses in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (199.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 63 mg/mL
Ethanol 1 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.