CAS No. 2101739-18-6
Batch:
Purity:99.25
Chemical Structure
Check the
RAD51-IN-17
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(4-chlorophenyl)methyl]-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one | |
|---|---|---|
| CAS Number | 2101739-18-6 | |
| Molecular Formula |
C22H16ClN3O |
|
| Molecular Weight (MW) | 373.83 | |
| SMILES | O=C1N(CC2=CC=C(Cl)C=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4 | |
| InChIKey | AQNDWTVLZSMOQU-FMIVXFBMSA-N |
RAD51-IN-17 is a quinazolinone-derived small molecule that functions as a potent inhibitor of the homologous recombinase RAD51. By targeting RAD51 and disrupting the homologous recombination (HR) DNA repair pathway, it prevents irradiation-induced RAD51 foci formation in response to DNA damage. Consequently, RAD51-IN-17 suppresses triple-negative breast cancer (TNBC) cell proliferation and sensitizes cancer cells to DNA-damaging treatments. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(200.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.